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apalutamide will reduce the level or influence of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medications which might be CYP3A4 substrates may end up in reduced publicity to these prescription drugs.nevirapine will l